ABSTRACT
Objective@#To evaluate the prognostic significance of comprehensive geriatric assessment (CGA) in Chinese elderly acute myeloid leukemia (AML) patients.@*Methods@#73 AML patients over the age of 60 were enrolled. CGA stratification included the following 3 instrument assessment: activity of daily living (ADL) ; instrumental activity of daily living (IADL) ; comorbidity score according to the Modified cumulative illness rating score for geriatrics (MCIRS-G) . According to CGA and age, the enrolled patients were grouped into 'fit’, 'unfit’ and 'frail’ categories.@*Results@#The median age of 73 elderly AML patients were 75 years old. According to CGA, 37 (50.1%) patients were classified as 'fit’, 14 (19.2%) as 'unfit’, and 22 (30.7%) as 'frail’. 33 (89.2%) patients in fit group received induction chemotherapy, or demethylation treatment, as 8 (57.9%) in unfit, 10 (45.5%) in frail. The overall response rate was 68.7%、62.5%, 75.0% in fit, unfit, and frail group, respectively (χ2=0.615, P=0.769) .The early mortality (8 weeks) in three groups were different: 5.4%, 7.1%, 27.3%, respectively (P<0.05) . The 1-year overall survival in the 'fit’, 'unfit’ and 'frail’ groups was 64.9%, 28.6% and 22.7%, respectively (P<0.05) . The CGA score, age, ECOG score, WHO classification (2016) were the prognostic factors of AML patients.@*Conclusion@#CGA can be used to determine the prognosis of elderly AML patients.
ABSTRACT
Objective To explore the effect of transradial approach in percutaneous coronary intervention for elderly patient with coronary artery disease,and provide reference for clinic. Methods There were 198 patients older than 70 years with coronary artery disease in our hospital from March 2007 to March 2013,who were divided into the radial group(n=100) and the femoral group(n=98) according to differ-ent puncture pathways. The X-ray exposure time,operative time,amount of contrast medium,the success rate of puncture,achievement ratio of operation and venous complications were compared and analyzed. Results The X-ray exposure time,operative time,amount of contrast me-dium,the success rate of puncture,achievement ratio of operation of 2 groups has no significant differences(P>0. 05). The venous complica-tion of radial group was less than that of femoral group,the difference was statistical significance(P<0. 05). Conclusion The transradial approach in percutaneous coronary intervention for elderly patient with coronary artery disease was feasible and safe,with less complication.